Nov 05 2020 Introduction In 2017 the US FDA granted approval of a subcutaneous SC injection form of rituximab as an alternative means of administration for patients with follicular lymphoma FL diffuse large B cell lymphoma DLBCL and chronic lymphocytic leukemia CLL . Although patients have reported a preference for SC rituximab R SC over intravenous
Feb 10 2022 The transition from intravenous IV to subcutaneous SQ insulin in the hospitalized patient with diabetes or hyperglycemia is a key step in patient care. This review article suggests a stepwise approach to the transition in order to promote safety and euglycemia.
In addition to being able to identify iron loading in the heart and liver the T2 technique can be used to assess the efficacy of iron chelators and t
Feb 01 2018 Introduction. The intravenous treatment with trastuzumab Herceptin Roche Basel Switzerland represents since a decade a gold standard in the treatment of patients with early and HER2 positive metastatic breast cancer in adjuvant setting .The alternative subcutaneous SC form of trastuzumab recently introduced proved to have similar
Research design and methods This is a prospective randomized controlled open label crossover trial in 20 octreotide treated rats. Three interventions 1 week apart in a randomized order were done in each rat. All 20 rats were given intraperitoneal and subcutaneous glucagon injections from which 5 rats were given intravenous glucagon injections and 15 rats received
Aug 29 2005 Design An open randomized controlled trial was used to compare intravenous versus subcutaneous morphine titration in persisting pain exacerbations in patients with cancer pain. Setting/subjects Thirty nine patients with cancer 21 intravenously 18 subcutaneously of the pain management department of the university hospital of Cologne
glycemic control achieved with intravenous insulin perfusion versus control subcutaneous insulin therapy over 24 hours. The second objective was to compare the MRI infarct growth between the 2 groups. The third objective was to compare the clinical and safety outcomes 90 days after stroke. The first and second objectives were
However the functional relevance of coronary collateral vessels in humans had also been a matter of debate for many years. w3 Much of this controversy was likely the result of inadequate means for gauging human coronary collaterals and the investigation of populations too small to be representative for all the patients with CAD. The latter is well illustrated by the fact that among
Median administration time 6 minutes vs. 2.6 to 3.0 hours chair/bed and overall hospital times were shorter with subcutaneous versus intravenous rituximab. Overall subcutaneous and intravenous rituximab had similar efficacy and safety
May 30 2019 Median overall survival was not reached with intravenous dosing vs 10.7 months with subcutaneous administration. Exposure to PF increased in a dose proportional manner over the range of intravenous doses. Median time to maximum observed serum concentration was 8 days after subcutaneous administration.
the subcutaneous administration of large volumes of fluids and electrolytes in order to achieve fluid maintenance or replacement. It is used in patients who are unable to tolerate sufficient oral intake and where intravenous access may be difficult to obtain or sustain or is inappropriate.
Mar 03 2021 Below is a summary of the difference between subcutaneous intramuscular and intravenous injection in tabular form. Summary Subcutaneous vs Intramuscular vs Intravenous Injection. The subcutaneous injection delivers a drug into the subcutaneous tissue under the skin. Meanwhile the intramuscular injection delivers the drug into a muscle.
Storey P. Subcutaneous infusion for control of cancer symptoms. J Pain Symptom Manage. 1990 5 33 41. Waldman CS Eason JR Rambohul E et al. Serum morphine levels a comparison between continuous SQ and IV infusion in post operative analgesia. Anaesthesia. 1984 39 768 771.
Mar 30 2018 Subcutaneous vs Intravenous Tanezumab for Knee Hip Osteoarthritis. Participants were adults with knee osteoarthritis and pain scores ≥4 on a 0 to 10 scale at screening. Intravenous IV and
Objectives To evaluate the long term efficacy and safety of subcutaneous SC tocilizumab TCZ versus intravenous IV TCZ including switching formulations in patients with rheumatoid arthritis RA and inadequate response to disease modifying antirheumatic drugs DMARDs . Methods Patients n=1262 were randomised 1 1 to receive TCZ SC 162 mg weekly
Mar 18 2020 Assessment of Thrombo prophylactic and Anti Inflammatory Effect of Unfractionated Heparin by Intravenous Infusion Versus Subcutaneous Injection in Critically Septic Shock Patients Estimated Study Start Date July 2020 Estimated Primary Completion Date August 24 2020 Estimated Study Completion Date December 31 2020
Dec 23 2020 Since the 1970s outpatient parenteral antimicrobial therapy OPAT has been a viable option for patients who require intravenous antibiotics when hospitalization is not warranted. While the benefits of OPAT as a measure to improve the efficiency of healthcare delivery i.e. reduced hospital days and patient satisfaction are well documented OPAT is
Apr 16 2021 A subcutaneous SC formulation of infliximab biosimilar CT P13 is approved in Europe for the treatment of adult patients with rheumatoid arthritis RA . It may offer improved efficacy versus intravenous IV infliximab formulations. A network meta regression was conducted using individual patient data from two randomised trials in patients with RA which
Phase 2 dose ranging study of the virologic efficacy and safety of the combination COVID 19 antibodies casirivimab and imdevimab in the outpatient setting
Assessment of response toxicity and quality of life. Tumor response was classified in accordance with the WHO criteria . Objective complete and partial responses were assessed by thoracic abdominal and pelvic computed tomography scan. Randomized Study of Intravenous versus Subcutaneous Interleukin 2 and IFNα in Patients with Good
the comparison of CT P13 SC versus CT P13 IV was limited to 30weeks as all patients randomised to CT P13 IV in the 3.5 trial were switched to CT P13 SC at week 30. However the availability of patient level data from the CT P13 3.1 and 3.5 trials allows a mixed treat ment comparison of CT P13 SC versus infliximab IV at weeks 30 and 54.
Apr 19 2021 For example for patients with immunodeficiency and some autoimmune conditions subcutaneous SC infusions of immunoglobulin SCIg may be used as an alternative to intravenous IV immunoglobulin IVIg . 1 Similarly the tumor necrosis factor inhibitor TNFi class of therapies widely used in the treatment of autoimmune conditions
Oct 18 2018 When oral hydration is insufficient intravenous IV fluid infusion is the commonly used route. However subcutaneous SC infusion of fluid also known as hypodermoclysis is an alternative route. Several studies have compared SC hydration to IV hydration with the main outcome being laboratory test of hydration or subjective assessment scores.
Rituximab 1000 mg IV monotherapy at Week 8 and Week 10 Belimumab placebo General follow up period Safety assessments Limited efficacy assessments For all patients Individualised follow up period Safety assessments Limited efficacy assessments Until CD19 B cells return to within normal range of baseline levels if
Patient controlled Analgesia A Comparison of Intravenous Versus Subcutaneous Hydromorphone. Anesthesiology September 1988 Assessment of the Potency and Intrinsic Activity of Systemic versus Intrathecal Opioids in Rats. Anesthesiology July 1997 Intravenous Versus Epidural Administration of Hydromorphone Effects on Analgesia and Recovery
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