Nov 01 2009 Intravenous self administration of nicotine in adult rats produced stable and robust acquisition of the nose poke response that was sustained over a variety of reinforcement schedules and that is consistent with previous levels of nicotine self administration reported by our group Guillem et al. 2005 2006 and others Donny et al. 1998 1999
Mar 19 2014 We exposed rats to intravenous nicotine self administration for 2 months. Using a combination of in vivo protocols electrical stimulations extracellular recordings and pharmacological manipulations we characterized the effects of 10 Hz stimulation of the ILCx on BNST excitatory responses under different conditions of exposure to nicotine.
Methods Rats were classified as sign or goal trackers during a Pavlovian conditioned approach paradigm. Rats then self administered intravenous nicotine 0.03 mg/kg infusions followed by extinction and cue induced reinstatement tests. We also
effects of IV nicotine will affect subsequent nicotine self administration in rats. Following an initial conditioning phase rats were allowed to self administer nicotine before undergoing an extinction and nicotine primed reinstatement phase. Learning history significantly affected self
Method 48 rats were given the opportunity to self administer at one of four low nicotine doses 15 7.5 3.75 0.0 µg/kg/infusion before and after self administering a higher dose of nicotine 60 µg/kg/infusion . A second group of 57 rats acquired self administration at the high nicotine dose before experiencing reduction.
methamphetamine self administration can be attained in adolescent rats and b adolescent nicotine exposure differentially alters oral methamphetamine self administration. Exposure to a low dose of nicotine 0.16 mg/kg but not a high dose of nicotine 0.64 mg/kg attenuated consumption and responding for methamphetamine during self
Thus far one study has examined extinction bursts for nicotine self administration using a 23 h access paradigm 1 . Here we examined extinction bursts using previously published and unpublished data in which rats were trained to self administer nicotine 0.03mg/kg/infusion or food pellets as a comparator in 1 h sessions under an FR5 Expand
Oct 20 2004 In an earlier study where animals were required to choose between cocaine and nicotine we have reported reliable nicotine self administration in adult rats Manzardo et al 2002 using the same
In the most classically used model ie. intravenous self administration of nicotine in the rat seeking behaviour is reinforced by the combination of intravenous
Apr 12 2019 After shaping rats were instrumented for IV self administration. During self administration tests rats in the ALC Alone received access to oral ethanol 15 v/v for meeting the schedule of reinforcement at one sipper tube e.g. right and saline infusions for meeting the schedule of reinforcement at the other sipper tube e.g. left .
Oct 01 2000 The present study determined if nornicotine a tobacco alkaloid and major nicotine metabolite in brain could reduce nicotine self administration in rats. Methods Each rat was prepared with an indwelling jugular catheter and trained to self administer intravenous nicotine 0.03 mg/kg per infusion .
Results After acute pretreatment 1 10 mg/kg for each enantiomer R nornicotine was more potent than S nornicotine in decreasing S nicotine self administration in contrast within the same dose range the nornicotine enantiomers were equipotent in decreasing sucrose maintained responding.
May 01 2002 Fig. 1. Intravenous nicotine self administration. a Mean ± SE of the daily number of responses in the device delivering the infusion of nicotine active and in the control device inactive calculated over the 42 d of testing.b Mean ± SE of the daily intake of nicotine calculated over the 42 d of testing. Nicotine induced self administration as shown by the
aim was to evaluate a new procedure for nicotine self admin istration in rats using infusion doses and durations that would more closely mimic the kinetics of nicotine delivery in human cigarette smokers. Third we sought to determine the effects of dopamine DA D 1 and D 2 receptor antagonists on nicotine self administration. Here we
Jan 01 2012 This behavior can be accurately modeled in the rat using an intravenous self administration IVSA paradigm. Initial attempts at establishing nicotine self administration had been problematic yet in recent times increasingly reliable models of nicotine self administration have been developed.
In this procedure rats are trained to self administer a drug of abuse e.g. nicotine cocaine by lever pressing in an operant box. Once rats exhibit stable drug intake the training drug is substituted with a testing compound. If the testing compound is self administered this indicates potential drug abuse liability.
May 01 2010 Rationale Nicotine intravenous self administration IVSA in rats has been conducted using a variety of methodological procedures with equally variable results. Objectives Here we addressed the importance of the type of response operandum and prior instrumental training with a natural reinforcer on nicotine IVSA and reinstatement. Methods Rats were
Nicotine and cocaine self administration using a multiple schedule of intravenous drug and sucrose reinforcement in rats Nicotine and neurodegeneration in ageing Nicotine and familial vulnerability to schizophrenia a discordant twin study Nicotine and ethanol interact during adolescence effects on the central cholinergic systems
Nov 01 1999 Rationale Robust intravenous i.v. nicotine self administration SA in rats has been reported by several laboratories including our own using fixed ratio FR schedules of reinforcement. Studies on other drugs of abuse however suggest that progressive ratio PR schedules may provide additional information not gained using FR schedules.
Sep 01 2002 Effect of RS baclofen and mecamylamine on nicotine intravenous self administration in rats. Mecamylamine mec was administered in a volume of 5 ml/kg 30 min before the start of the experimental session. Nicotine intravenous self administration was in a dose of 0.06 mg/kg/injection.
Oct 06 2020 Rodents are frequently used to model drug addiction yet their genetic relevance to human addictive behaviors especially the mounting genome wide association study GWAS findings is poorly understood. Considering a possible gateway drug role of nicotine NIC we modeled NIC addiction specifically NIC sensitization SST and self administration SA in
Jun 19 2021 81 cKO mice display increased intravenous IV nicotine self administration consistent with a role 82 for VGLUT1 mediated glutamate co release at this circuit in opposing nicotine intake. 83 84 METHODS 85 Animals 86 Mice were used in accordance with the University of California San Diego and the University of
NICOTINE SELF ADMINISTRATION IN ADOLESCENT MALE AND FEMALE RATS by Rachel L. Schassburger iv Tobacco product use is the leading preventable cause of death in the United States. Nearly 90 The sex difference in adult use and relapse can be demonstrated in rat models of self administration suggesting a biological basis underlying the
Figure 1. Contingent oral menthol supports stable i.v. nicotine self administration. A Female adolescent Sprague Dawley rats received concurrent oral menthol or vehicle cue and i.v. nicotine or saline upon the completion of a fixed ratio 10 reinforcement schedule on the lickometer. The number of infusions obtained per session by the menthol nicotine group was
in a rodent model of nicotine self administration. In the nicotine study subjects self administered nicotine 0.03 mg/kg/inf under a fixed ratio 3 FR3 60 s timeout TO schedule of reinforcement. The effects of bupropion on food maintained responding using two levels of food deprivation food deprived and food satiated were used to
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